Ntau cov tshuaj npaj tau siv rau hauv cov ntsiav tshuaj, granule, hmoov, thiab kua daim ntawv.Feem ntau, cov ntsiav tshuaj tsim nyob rau hauv ib daim ntawv qhia rau cov neeg mob nqos los yog zom ib tug meej koob tshuaj.Txawm li cas los xij, tshwj xeeb tshaj yog cov neeg mob laus thiab cov menyuam yaus muaj teeb meem zom lossis nqos cov ntaub ntawv ntau npaum li cas.4 Yog li ntawd, ntau tus menyuam yaus thiab cov neeg laus tsis kam noj cov tshuaj no vim muaj kev ntshai ntawm asphyxiation.Orally dissolving tablets (ODTs) tau tshwm sim los ua kom tau raws li qhov xav tau no.Txawm li cas los xij, rau qee tus neeg mob, kev ntshai ntawm kev nqos cov khoom noj khoom haus (ntsiav tshuaj, tshuaj ntsiav), thiab kev pheej hmoo ntawm asphyxiation tseem nyob txawm tias luv luv dissolution / disintegration lub sij hawm.Qhov ncauj nyias zaj duab xis (OTF) cov tshuab xa tshuaj yog ib qho kev xaiv zoo dua nyob rau hauv cov xwm txheej no.Lub qhov ncauj bioavailability ntawm ntau cov tshuaj tsis txaus vim yog cov enzymes, cov metabolism hauv thawj zaug, thiab pH ntawm lub plab.Cov tshuaj zoo li no tau muab tshuaj rau niam txiv thiab tau pom tias muaj kev ua raws li tus neeg mob tsawg.Cov xwm txheej zoo li no tau ua rau txoj hauv kev rau kev lag luam tshuaj los txhim kho lwm txoj hauv kev rau kev thauj mus los ntawm cov tshuaj los ntawm kev tsim cov yeeb yaj kiab nyias nyias / dissolving hauv qhov ncauj.Kev ntshai ntawm kev poob dej, uas tej zaum yuav muaj kev pheej hmoo nrog ODTs, tau cuam tshuam nrog cov pab pawg neeg mob no.Kev tawg sai sai / kev sib cais ntawm OTF cov tshuaj xa khoom yog ib qho kev xaiv zoo dua rau ODTs hauv cov neeg mob uas muaj kev ntshai ntawm asphyxiation.Thaum lawv muab tso rau ntawm tus nplaig, OTFs tam sim ntawd wetted nrog qaub ncaug.Raws li qhov tshwm sim, lawv tau tawg thiab / lossis yaj kom tso cov tshuaj rau lub cev thiab / lossis kev nqus hauv zos.
Qhov ncauj disintegrating / dissolving films los yog strips yuav txhais tau raws li nram no: "Cov no yog cov tshuaj xa cov tshuaj uas lawv sai sai tso cov tshuaj los ntawm dissolving los yog adhering nyob rau hauv lub mucosa nrog qaub ncaug nyob rau hauv ob peb vib nas this vim nws muaj dej-soluble polymers thaum nws muab tso rau. nyob rau hauv lub qhov ncauj kab noj hniav los yog ntawm tus nplaig. "Lub sublingual mucosa muaj cov membrane permeability siab vim nws cov qauv nyias nyias thiab vascularization siab.Vim qhov no cov ntshav ceev ceev, nws muaj bioavailability zoo heev.Enhanced systemic bioavailability yog vim muaj kev cuam tshuam thawj zaug thiab zoo permeability yog vim muaj ntshav txaus thiab lymphatic ncig.Tsis tas li ntawd, lub qhov ncauj mucosa yog ib txoj hauv kev zoo heev thiab xaiv txoj hauv kev ntawm kev xa tshuaj vim yog thaj chaw loj thiab yooj yim ntawm daim ntawv thov rau kev nqus.6 Feem ntau, OTFs yog tus cwj pwm zoo li nyias thiab hloov tau yooj yim polymer txheej, nrog lossis tsis muaj plasticizers hauv. lawv cov ntsiab lus.Lawv tuaj yeem hais tias tsis tshua muaj kev cuam tshuam thiab ntau dua rau cov neeg mob, vim tias lawv nyias nyias thiab hloov tau yooj yim hauv lawv cov qauv ntuj.Cov yeeb yaj kiab nyias yog cov txheej txheem polymeric uas muab ntau yam kev xav tau ntawm kev xa tshuaj.Hauv kev tshawb fawb, cov yeeb yaj kiab nyias tau qhia lawv lub peev xwm xws li kev txhim kho thawj zaug ntawm cov tshuaj thiab lub sijhawm ntawm cov nyhuv no, txo qhov zaus ntawm kev siv tshuaj, thiab ua kom cov tshuaj muaj txiaj ntsig zoo.Nrog nyias-zaj duab xis thev naus laus zis, nws tuaj yeem ua tau zoo los tshem tawm cov kev mob tshwm sim ntawm cov tshuaj thiab txo cov metabolism hauv cov khoom siv los ntawm cov enzymes proteolytic.Cov yeeb yaj kiab zoo tshaj plaws yuav tsum muaj cov khoom xav tau ntawm kev xa cov tshuaj, xws li lub peev xwm thauj cov tshuaj tsim nyog, dispersion / dissolution sai, los yog daim ntawv thov ntev thiab tsim nyog formulation stability.Tsis tas li ntawd, lawv yuav tsum yog nontoxic, biodegradable thiab biocompatible.
Raws li American Food and Drug Administration (FDA), OTF txhais tau tias "nrog rau ib lossis ntau cov khoom xyaw tshuaj nquag (APIs), ib qho yooj yim thiab tsis nkig strips uas muab tso rau ntawm tus nplaig ua ntej nkag mus rau hauv plab hnyuv, aiming rau kev tawg sai lossis tawg hauv cov qaub ncaug. "Thawj cov tshuaj OTF yog Zuplenz (Ondansetron HCl, 4-8 mg) thiab tau pom zoo hauv 2010. Suboxon (buprenorphine thiab naloxan) sai sai raws li qhov thib ob pom zoo.Cov ntaub ntawv pov thawj qhia tau tias plaub ntawm tsib tus neeg mob xaiv qhov ncauj qhov ncauj qhov ncauj / disintegrating dosage forms tshaj li cov qauv ntawm qhov ncauj khoom noj khoom haus.7 Tam sim no, nyob rau hauv ntau yam tshuaj thiab khw muag khoom, tshwj xeeb tshaj yog nyob rau hauv hnoos, mob khaub thuas, mob caj pas, erectile kawg tsis ua hauj lwm. , kev ua xua, mob hawb pob, mob plab hnyuv, mob, snoring tsis txaus siab, teeb meem pw tsaug zog, thiab multivitamin ua ke, thiab lwm yam. OTFs muaj thiab nce ntxiv.13 Fast-dissolving qhov ncauj films muaj ntau yam zoo dua lwm yam khoom noj, xws li yooj thiab nce kev ua tau zoo ntawm API.Tsis tas li ntawd, cov yeeb yaj kiab hauv qhov ncauj muaj kev sib cais thiab kev sib cais nrog cov kua qaub me me hauv tsawg dua ib feeb piv nrog ODTs.1
Ib qho OTF yuav tsum muaj cov yam ntxwv zoo hauv qab no
-Nws yuav tsum saj zoo
-Cov tshuaj yuav tsum muaj dej noo heev thiab soluble hauv cov qaub ncaug
-Nws yuav tsum muaj qhov tsim nyog tension resistance
-Nws yuav tsum tau ionized nyob rau hauv lub qhov ncauj kab noj hniav pH
-Nws yuav tsum tau nkag mus rau lub qhov ncauj mucosa
-Nws yuav tsum muaj peev xwm ua tau sai
OTF qhov zoo dua li lwm cov ntawv siv tshuaj
- Tswv yim
- Tsis tas yuav siv dej
-Tuaj yeem siv tau yam nyab xeeb txawm tias nkag mus rau hauv dej tsis tau (xws li mus ncig)
- Tsis muaj kev pheej hmoo ntawm kev ua tsis taus pa
- Txhim kho stability
- Yooj yim rau kev thov
- Yooj yim thov rau cov neeg mob hlwb thiab tsis sib haum xeeb
-Muaj me me lossis tsis muaj qhov seem hauv lub qhov ncauj tom qab thov
-Bypasses lub plab zom mov thiab yog li ua kom bioavailability
- Tsawg npaum li cas thiab cov kev mob tshwm sim tsawg
-Nws muab ntau npaum li cas yog thaum piv rau cov ntaub ntawv ua kua
-Tsis tas yuav ntsuas, uas yog qhov tsis zoo tseem ceeb hauv cov ntawv ua kua
-Nyob zoo nyob rau hauv lub qhov ncauj
- Muab qhov pib sai sai ntawm cov teebmeem hauv cov xwm txheej uas yuav tsum tau muaj kev cuam tshuam sai, piv txwv li, kev tsis haum tshuaj xws li mob hawb pob thiab kab mob hauv lub cev.
-Txhim kho tus nqi nqus thiab tus nqi ntawm cov tshuaj
-Muaj kev txhim kho bioavailability rau cov tshuaj tsis muaj dej-soluble, tshwj xeeb tshaj yog los ntawm kev muab thaj chaw loj heev thaum tawg sai
-Tsis tiv thaiv ib txwm ua haujlwm xws li hais lus thiab haus dej
- Muab kev tswj hwm cov tshuaj uas muaj kev pheej hmoo siab ntawm kev cuam tshuam hauv plab hnyuv
-Nws muaj kev nthuav dav kev lag luam thiab cov khoom lag luam ntau yam
-Tau tsim thiab muab tso rau hauv kev ua lag luam hauv 12-16 lub hlis
Kab lus no yog los ntawm Is Taws Nem, thov hu rau kev ua txhaum cai!
©Copyright2021 Turk J Pharm Sci, luam tawm los ntawm Galenos Publishing House.
Post lub sij hawm: Dec-01-2021