Metformin muaj kev tshawb pom tshiab

1. Nws yuav tsum txhim kho txoj kev pheej hmoo ntawm lub raum tsis ua haujlwm thiab tuag los ntawm kab mob raum
WuXi AppTec cov ntsiab lus pab pawg Medical New Vision tau tshaj tawm xov xwm hais tias kev tshawb fawb ntawm 10,000 tus neeg tau pom tias metformin tuaj yeem txhim kho txoj kev pheej hmoo ntawm lub raum tsis ua haujlwm thiab tuag los ntawm kab mob raum.

Ib txoj kev tshawb fawb luam tawm nyob rau hauv American Diabetes Association (ADA) phau ntawv journal "Kev Kho Mob Ntshav Qab Zib" (Kev Kho Mob Ntshav Qab Zib) tau qhia tias cov tshuaj thiab kev soj ntsuam kev ciaj sia ntawm ntau dua 10,000 tus neeg tau pom tias cov neeg mob ntshav qab zib hom 2 uas mob raum mob (CKD) noj Metformin yog txuam nrog. txo qhov kev pheej hmoo ntawm kev tuag thiab mob raum kawg (ESRD), thiab tsis ua rau muaj kev pheej hmoo ntawm lactic acidosis.

Mob raum mob yog ib qho teeb meem ntawm ntshav qab zib.Txhawm rau txiav txim siab tias cov neeg mob mob raum mob me me tuaj yeem raug tshuaj metformin, pab pawg tshawb fawb tau tshawb xyuas 2704 cov neeg mob hauv txhua ob pawg noj metformin thiab tsis noj metformin.

Cov txiaj ntsig tau pom tias piv nrog cov neeg tsis noj cov tshuaj metformin, cov neeg mob uas tau noj metformin tau txo qis 35% ntawm kev pheej hmoo ntawm kev tuag tag nrho thiab 33% txo qis ntawm kev pheej hmoo ntawm kev mob raum mus rau theem kawg.Cov txiaj ntsig no maj mam tshwm sim tom qab li 2.5 xyoo ntawm kev noj tshuaj metformin.

Raws li tsab ntawv ceeb toom, nyob rau xyoo tas los no, US FDA cov lus qhia pom zoo kom txo qis kev siv metformin hauv cov neeg mob ntshav qab zib hom 2 uas muaj kab mob raum, tab sis tsuas yog cov neeg mob raum mob me.Rau cov neeg mob nruab nrab (theem 3B) thiab mob raum mob hnyav, kev siv metformin tseem muaj teeb meem.

Dr. Katherine R. Tuttle, tus xibfwb ntawm University of Washington hauv Tebchaws Meskas, tau hais tias: “Cov txiaj ntsig ntawm txoj kev tshawb fawb no ua rau muaj kev ntseeg siab dua.Txawm nyob rau hauv cov neeg mob uas mob raum mob hnyav, qhov kev pheej hmoo ntawm lactic acidosis yog tsawg heev.Rau cov neeg mob uas muaj ntshav qab zib hom 2 thiab mob raum mob ntev, metformin yuav yog ib qho kev tiv thaiv kev tuag thiab Ib qho tshuaj tseem ceeb rau lub raum tsis ua haujlwm, tab sis vim qhov no yog kev tshawb nrhiav rov qab thiab kev soj ntsuam, cov txiaj ntsig yuav tsum tau muab txhais ua tib zoo. "

2. Muaj ntau yam kev kho mob muaj peev xwm ntawm cov tshuaj yeeb tshuaj metformin
Metformin tuaj yeem hais tau tias yog cov tshuaj qub qub uas tau siv sijhawm ntev.Hauv kev nce qib ntawm kev tshawb fawb tshuaj hypoglycemic, xyoo 1957, tus kws tshawb fawb Fab Kis Stern tau luam tawm nws cov txiaj ntsig kev tshawb fawb thiab ntxiv cov lilac extract uas muaj kev ua haujlwm hypoglycemic hauv tshis taum.Alkali, npe hu ua metformin, Glucophage, uas txhais tau hais tias noj qab zib.

Hauv xyoo 1994, metformin tau raug pom zoo los ntawm US FDA rau kev siv hauv hom 2 mob ntshav qab zib.Metformin, raws li cov tshuaj muaj cai rau kev kho mob ntshav qab zib hom 2, tau teev tseg raws li cov tshuaj hypoglycemic thawj zaug hauv ntau txoj kev kho mob hauv tsev thiab txawv teb chaws.Nws muaj qhov zoo ntawm cov nyhuv hypoglycemic, tsis tshua muaj kev pheej hmoo ntawm hypoglycemia, thiab tus nqi qis.Tam sim no nws yog cov tshuaj siv dav tshaj plaws Ib qho ntawm cov tshuaj hypoglycemic.

Raws li kev tshuaj ntsuam xyuas lub sijhawm, nws kwv yees tias muaj ntau dua 120 lab cov neeg siv ntawm metformin thoob ntiaj teb.

Nrog rau kev tshawb fawb tob zuj zus, cov peev txheej kho tau ntawm metformin tau txuas ntxiv mus.Ntxiv rau qhov kev tshawb pom tshiab, metformin kuj tau pom tias muaj ze li ntawm 20 qhov teebmeem.

1. Anti-aging nyhuv
Tam sim no, US Food and Drug Administration tau pom zoo rau kev sim tshuaj "siv metformin los tiv thaiv kev laus".Qhov laj thawj yog vim li cas cov kws tshawb fawb txawv teb chaws siv metformin los ua cov tshuaj tiv thaiv kev laus tuaj yeem yog vim tias metformin tuaj yeem nce cov pa oxygen molecules tso rau hauv cov hlwb.Qhov tseem ceeb tshaj, qhov no zoo li ua rau lub cev muaj zog thiab ua kom lub neej ntev.

2. poob phaus
Metformin yog tus neeg sawv cev hypoglycemic uas tuaj yeem poob phaus.Nws tuaj yeem ua kom cov tshuaj insulin rhiab heev thiab txo cov rog synthesis.Rau ntau hom 2 qab zib lovers, yuag poob nws tus kheej yog ib yam uas yuav ua rau muaj kev ruaj ntseg ntawm cov ntshav qab zib.

Ib txoj kev tshawb fawb los ntawm United States Diabetes Prevention Program (DPP) pab pawg tshawb fawb tau pom tias nyob rau hauv ib qho kev tshawb fawb tsis pom kev ntawm 7-8 xyoo, cov neeg mob uas tau txais kev kho mob metformin poob qhov hnyav ntawm qhov nruab nrab ntawm 3.1 kg.

3. Txo qhov kev pheej hmoo ntawm nchuav menyuam thiab yug ntxov ntxov rau qee cov poj niam cev xeeb tub
Cov kev tshawb fawb tshiab tshaj tawm hauv The Lancet qhia tias metformin tuaj yeem txo qis kev pheej hmoo ntawm kev nchuav menyuam thiab kev yug menyuam ntxov hauv qee cov poj niam cev xeeb tub.

Raws li cov lus ceeb toom, cov kws tshawb fawb los ntawm Norwegian University of Science thiab Technology (NTNU) thiab Tsev Kho Mob St. Olavs tau ua qhov kev tshawb fawb ze li ntawm 20 xyoo thiab pom tias cov neeg mob polycystic zes qe menyuam noj cov tshuaj metformin thaum kawg ntawm 3 lub hlis ntawm cev xeeb tub tuaj yeem txo qis tom qab. lub sij hawm nchuav menyuam thiab nchuav menyuam.Kev pheej hmoo ntawm kev yug ntxov ntxov.

4. Tiv thaiv qhov mob los ntawm smog
Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias pab pawg coj los ntawm xibfwb Scott Budinger ntawm Northwestern University tau lees paub hauv nas tias metformin tuaj yeem tiv thaiv kev mob tshwm sim los ntawm smog, tiv thaiv lub cev tiv thaiv kab mob los ntawm kev tso tawm cov molecule txaus ntshai rau hauv cov ntshav, inhibit qhov tsim ntawm arterial thrombosis, thiab yog li ntawd. txo cov hlab plawv.Txoj kev pheej hmoo ntawm kab mob.

5. Kev tiv thaiv kab mob plawv
Metformin muaj cov txiaj ntsig tiv thaiv kab mob plawv thiab tam sim no tsuas yog cov tshuaj hypoglycemic pom zoo los ntawm cov txheej txheem ntshav qab zib kom muaj pov thawj tseeb ntawm cov txiaj ntsig ntawm lub plawv.Cov kev tshawb fawb tau pom tias kev kho mob ntev ntev ntawm metformin muaj feem cuam tshuam nrog kev txo qis ntawm cov kab mob plawv hauv cov neeg mob ntshav qab zib hom 2 tshiab thiab cov neeg mob ntshav qab zib hom 2 uas twb tau tsim cov kab mob plawv.

6. Txhim kho polycystic zes qe menyuam syndrome
Polycystic zes qe menyuam syndrome yog ib hom kab mob sib txawv uas tshwm sim los ntawm hyperandrogenemia, zes qe menyuam tsis ua haujlwm, thiab polycystic zes qe menyuam morphology.Nws pathogenesis tsis meej, thiab cov neeg mob feem ntau muaj ntau theem ntawm hyperinsulinemia.Cov kev tshawb fawb tau pom tias metformin tuaj yeem txo qis insulin tsis kam, rov ua haujlwm ntawm ovulation, thiab txhim kho hyperandrogenemia.

7. Txhim kho txoj hnyuv
Cov kev tshawb fawb tau pom tias metformin tuaj yeem kho qhov feem ntawm cov plab hnyuv thiab ua rau nws hloov mus rau qhov kev coj ua uas muaj txiaj ntsig zoo rau kev noj qab haus huv.Nws muab qhov chaw nyob zoo rau cov kab mob uas muaj txiaj ntsig hauv cov hnyuv, yog li txo cov ntshav qab zib thiab tswj kev tiv thaiv kab mob zoo.

8. Nws yuav tsum tau kho qee qhov kev puas hlwb
Tsis ntev los no, cov kws tshawb fawb ntawm McGill University tau tshawb pom tias metformin tuaj yeem kho qee yam ntawm Fragile X syndrome nrog autism, thiab qhov kev tshawb fawb tshiab no tau luam tawm nyob rau hauv phau ntawv journal Nature Medicine, ib qho teeb meem ntawm Nature.Tam sim no, autism yog ib qho ntawm ntau yam mob uas cov kws tshawb fawb ntseeg tias tuaj yeem kho nrog metformin.

9. Rov qab pulmonary fibrosis
Cov kws tshawb fawb ntawm University of Alabama ntawm Birmingham pom tias hauv tib neeg cov neeg mob uas muaj idiopathic pulmonary fibrosis thiab nas pulmonary fibrosis qauv raug ntxias los ntawm bleomycin, cov haujlwm ntawm AMPK hauv cov ntaub so ntswg yog txo, thiab cov ntaub so ntswg tiv thaiv cov hlwb apoptotic myofibroblasts nce.

Kev siv metformin los qhib AMPK hauv myofibroblasts tuaj yeem rov ua kom cov hlwb no rov ua rau apoptosis.Tsis tas li ntawd, hauv cov qauv nas, metformin tuaj yeem ua kom nrawm nrawm ntawm cov ntaub so ntswg uas twb tau tsim lawm.Txoj kev tshawb no qhia tau hais tias metformin lossis lwm yam AMPK agonists tuaj yeem siv los thim rov qab fibrosis uas twb tshwm sim lawm.

10. Pab txiav luam yeeb
Cov kws tshawb fawb ntawm University of Pennsylvania tau pom tias kev siv nicotine mus sij hawm ntev tuaj yeem ua rau muaj kev ua haujlwm ntawm AMPK signaling pathway, uas yog inhibited thaum lub sij hawm tshem tawm nicotine.Yog li ntawd, lawv tau txiav txim siab tias yog siv tshuaj los ua kom lub AMPK taw qhia txoj hauv kev, nws yuav txo tau cov lus teb tawm.

Metformin yog AMPK agonist.Thaum cov kws tshawb fawb tau muab metformin rau cov nas uas muaj nicotine tshem tawm, lawv pom tias nws txo qis cov nas tshem tawm.Lawv cov kev tshawb fawb qhia tias metformin tuaj yeem siv los pab txiav luam yeeb.

11. Anti-inflammatory nyhuv
Yav dhau los, kev tshawb fawb txog kev kho mob thiab kev kho mob tau pom tias metformin tsis tuaj yeem txhim kho cov mob ntev los ntawm kev txhim kho cov kab mob metabolic xws li hyperglycemia, insulin tsis kam thiab atherosclerotic dyslipidemia, tab sis kuj muaj cov tshuaj tiv thaiv ncaj qha.

Cov kev tshawb fawb tau taw qhia tias metformin tuaj yeem cuam tshuam qhov mob, feem ntau los ntawm AMP-activated protein kinase (AMPK)-dependent lossis ywj siab inhibition ntawm nuclear transcription factor B (NFB).

12. Rov qab kev paub tsis meej
Cov kws tshawb fawb ntawm University of Texas ntawm Dallas tau tsim ib tus qauv nas uas ua raws li qhov mob ntsig txog kev paub tsis meej.Lawv siv cov qauv no los ntsuas qhov ua tau zoo ntawm ntau yam tshuaj.

Cov txiaj ntsig kev sim qhia tau hais tias kev kho cov nas nrog 200 mg / kg lub cev qhov hnyav ntawm metformin rau 7 hnub tuaj yeem thim rov qab qhov kev xav tsis zoo los ntawm qhov mob.

Gabapentin, uas kho neuralgia thiab qaug dab peg, tsis muaj txiaj ntsig zoo li no.Qhov no txhais tau hais tias metformin tuaj yeem siv los ua cov tshuaj qub los kho kev puas hlwb hauv cov neeg mob neuralgia.

13. inhibit qog loj hlob
Ob peb hnub dhau los, raws li Singularity.com, cov kws tshawb fawb los ntawm European Institute of Oncology tau tshawb pom tias metformin thiab yoo mov tuaj yeem ua haujlwm sib koom ua ke los tiv thaiv kev loj hlob ntawm cov qog nas.

Los ntawm kev tshawb fawb ntxiv, nws tau pom tias metformin thiab yoo mov inhibit qog loj hlob los ntawm txoj kev PP2A-GSK3β-MCL-1.Cov kev tshawb fawb tau luam tawm ntawm Cancer Cell.

14. tuaj yeem tiv thaiv macular degeneration
Dr. Yu-Yen Chen los ntawm Taichung Veterans General Tsev Kho Mob hauv Taiwan, Tuam Tshoj tsis ntev los no tau tshawb pom tias qhov xwm txheej ntawm lub hnub nyoog ntsig txog macular degeneration (AMD) hauv cov neeg mob ntshav qab zib hom 2 noj metformin qis dua.Qhov no qhia tau hais tias thaum tswj ntshav qab zib, cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm metformin muaj kev tiv thaiv ntawm AMD.

15. Los yog tuaj yeem kho cov plaub hau poob
Pab pawg ntawm Huang Jing, kws tshawb fawb Suav ntawm University of California, Los Angeles, tau tshawb pom tias cov tshuaj xws li metformin thiab rapamycin tuaj yeem ua rau cov hauv paus plaub hau nyob rau theem so ntawm cov nas kom nkag mus rau theem kev loj hlob thiab txhawb kev loj hlob ntawm cov plaub hau.Cov kev tshawb fawb cuam tshuam tau luam tawm nyob rau hauv phau ntawv xov xwm kev kawm nto moo Cell Reports.

Ntxiv mus, thaum cov kws tshawb fawb siv metformin los kho cov neeg mob polycystic zes qe menyuam syndrome hauv Suav teb thiab Is Nrias teb, lawv kuj tau pom tias metformin cuam tshuam nrog txo cov plaub hau.

16. Rov qab muaj hnub nyoog lom neeg
Tsis ntev los no, lub vev xaib raug cai ntawm thoob ntiaj teb kev tshawb fawb thiab thev naus laus zis phau ntawv xov xwm "Nature" tau tshaj tawm xov xwm blockbuster.Cov ntawv ceeb toom qhia tau hais tias kev tshawb fawb me me hauv California tau pom thawj zaug tias nws muaj peev xwm thim rov qab lub sijhawm ntawm tib neeg epigenetic moos.Nyob rau xyoo tas los no, cuaj tus neeg tuaj yeem noj qab haus huv tau siv cov tshuaj hormones loj hlob thiab ob hom tshuaj ntshav qab zib, suav nrog metformin.Ntsuas los ntawm kev txheeb xyuas cov cim ntawm tus neeg lub genome, lawv lub hnub nyoog lom neeg tau poob los ntawm qhov nruab nrab ntawm 2.5 xyoo.

17. Cov tshuaj sib xyaw ua ke tuaj yeem kho mob cancer mis triple-negative
Ob peb hnub dhau los, ib pab neeg coj los ntawm Dr. Marsha nplua nuj rosner ntawm University of Chicago tau tshawb pom tias kev sib xyaw ntawm metformin thiab lwm yam tshuaj qub, heme (panhematin), tuaj yeem tsom rau kev kho mob qog noj ntshav ntawm lub mis triple-negative uas ua phem rau poj niam txoj kev noj qab haus huv. .

Thiab muaj pov thawj tias cov tswv yim kho mob no yuav ua tau zoo rau ntau yam mob qog noj ntshav xws li mob ntsws cancer, mob raum, mob qog noj ntshav, mob qog nqaij hlav prostate thiab mob myeloid leukemia.Cov kev tshawb fawb cuam tshuam tau luam tawm nyob rau hauv phau ntawv journal Nature.

18. Tej zaum yuav txo tau qhov tsis zoo ntawm glucocorticoids
Tsis ntev los no, "Lancet-Diabetes thiab Endocrinology" luam tawm ib qho kev tshawb fawb-cov txiaj ntsig ntawm txoj kev tshawb fawb pom tau tias nyob rau theem 2 kev sim tshuaj, metformin siv rau cov neeg mob uas muaj kab mob ntev tuaj yeem txhim kho kev noj qab haus huv ntawm metabolic thiab txo cov kev kho mob glucocorticoid hnyav.

Cov kev sim tau pom tias metformin tuaj yeem ua los ntawm qhov tseem ceeb metabolic protein AMPK, thiab cov txheej txheem ntawm kev ua haujlwm yog qhov txawv ntawm glucocorticoids, thiab muaj peev xwm thim rov qab cov kev mob tshwm sim los ntawm kev siv ntau ntawm glucocorticoids.

19. Cia siab tias yuav kho ntau yam sclerosis
Yav dhau los, ib pab neeg tshawb fawb coj los ntawm Robin JM Franklin ntawm University of Cambridge thiab nws tus thwj tim Peter van Wijngaarden tau luam tawm ib tsab xov xwm nyob rau hauv cov ntawv xov xwm saum toj kawg nkaus "Cell Stem Cells" uas lawv pom ib hom tshwj xeeb ntawm cov laus neural qia hlwb uas tuaj yeem rov zoo tom qab kho nrog. metformin.Hauv kev teb rau qhov sib txawv-txhim kho cov cim qhia, nws rov tshwm sim cov tub ntxhais hluas tseem ceeb thiab ntxiv txhawb kev tsim kho cov paj hlwb myelin.

Qhov kev tshawb pom no txhais tau hais tias metformin yuav tsum tau siv rau hauv kev kho mob ntawm cov kab mob neurodegeneration uas cuam tshuam tsis zoo, xws li ntau yam sclerosis.